Toripalimab Plus Concurrent Chemo-radiotherapy for Unresectable Locally Recurrent Nasopharyngeal Carcinoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

226

Participants

Timeline

Start Date

July 3, 2020

Primary Completion Date

July 31, 2025

Study Completion Date

July 31, 2027

Conditions
Nasopharyngeal CarcinomaChemotherapyRadiotherapyPD-1 Treatment
Interventions
DRUG

Toripalimab plus concurrent chemo-radiotherapy

"1. Toripalimab: 240 mg, intravenous injection over 60 minutes (Q3W); 2 cycles of toripalimab are concurrently used during radiotherapy and other 9 cycles of toripalimab are used after the end of radiotherapy. (A total of 11 cycles).~2. Concurrent cisplatin chemotherapy: cisplatin is given at a dose of 100 mg/m2 via a continuous intravenous infusion during radiotherapy and starts on the 1st day of radiotherapy for 2 cycles. 1 cycles per 3 weeks.~3. IMRT: PTVnx#60.0Gy/27Fr/2.22Gy; PTVnd# 60-64Gy/27Fr/2.22-2.37Gy; PTV1#54Gy/27Fr/2.00Gy"

DRUG

Concurrent chemo-radiotherapy

"1. Concurrent cisplatin chemotherapy: cisplatin is given at a dose of 100 mg/m2 via a continuous intravenous infusion during radiotherapy and starts on the 1st day of radiotherapy for 2 cycles. 1 cycles per 3 weeks.~2. IMRT: PTVnx#60.0Gy/27Fr/2.22Gy; PTVnd# 60-64Gy/27Fr/2.22-2.37Gy; PTV1#54Gy/27Fr/2.00Gy"

Trial Locations (6)

510060

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

510095

NOT_YET_RECRUITING

Cancer Center of Guangzhou Medical University, Guangzhou

512025

NOT_YET_RECRUITING

Yuebei People's Hospital, Shaoguan

519000

NOT_YET_RECRUITING

The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai

528403

NOT_YET_RECRUITING

Zhongshan People's Hospital, Zhongshan

543002

RECRUITING

Wuzhou Red Cross Hospital, Wuzhou

All Listed Sponsors
collaborator

Affiliated Cancer Hospital & Institute of Guangzhou Medical University

OTHER

collaborator

Zhongshan People's Hospital, Guangdong, China

OTHER

collaborator

Yuebei People's Hospital

OTHER

collaborator

Wuzhou Red Cross Hospital

OTHER

collaborator

Fifth Affiliated Hospital, Sun Yat-Sen University

OTHER

lead

Sun Yat-sen University

OTHER