Reduced vs Conventional Dosage Intensity-modulated Radiotherapy for Chemotherapy-sensitive Stage II-III Nasopharyngeal Carcinoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

508

Participants

Timeline

Start Date

August 18, 2020

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2028

Conditions
Nasopharyngeal CarcinomaRadiotherapyChemotherapy
Interventions
RADIATION

reduced dosage IMRT

"1. Gemcitabine plus cisplatin induction chemotherapy: gemcitabine is injected intravenously at the dose of 1000 mg/m2 on the 1st and 8th day (within 30 minutes) for 3 cycles; cisplatin is injected intravenously at the dose of 80 mg/m2 on the 1st day, for 3 cycles. 1 cycles per 3 weeks.~2. Concurrent cisplatin chemotherapy: cisplatin is given at a dose of 100 mg/m2 via a continuous intravenous infusion during radiotherapy and starts on the 1st day of radiotherapy for 2 cycles. 1 cycles per 3 weeks.~3. IMRT: PTVnx:63.6Gy/30Fr/2.12Gy; PTVnd:63.6Gy/30Fr/2.12Gy; PTV1:54Gy/30Fr/1.8Gy; PTV2:49.2Gy/30Fr/1.64Gy"

RADIATION

conventional dosage IMRT

"1. Gemcitabine plus cisplatin induction chemotherapy: gemcitabine is injected intravenously at the dose of 1000 mg/m2 on the 1st and 8th day (within 30 minutes) for 3 cycles; cisplatin is injected intravenously at the dose of 80 mg/m2 on the 1st day, for 3 cycles. 1 cycles per 3 weeks.~2. Concurrent cisplatin chemotherapy: cisplatin is given at a dose of 100 mg/m2 via a continuous intravenous infusion during radiotherapy and starts on the 1st day of radiotherapy for 2 cycles. 1 cycles per 3 weeks.~3. IMRT: PTVnx:69.96Gy/33Fr/2.12Gy; PTVnd:69.96Gy/33Fr/2.12Gy; PTV1:59.4Gy/33Fr/1.8Gy; PTV2:54Gy/33Fr/1.64Gy"

Trial Locations (6)

169610

NOT_YET_RECRUITING

National Cancer Centre Singapore, Singapore

510060

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

510095

NOT_YET_RECRUITING

Cancer Center of Guangzhou Medical University, Guangzhou

512025

NOT_YET_RECRUITING

Yuebei People's Hospital, Shaoguan

528403

RECRUITING

Zhongshan People's Hospital, Zhongshan

543002

NOT_YET_RECRUITING

Wuzhou Red Cross Hospital, Wuzhou

All Listed Sponsors
collaborator

National Cancer Centre, Singapore

OTHER

collaborator

Affiliated Cancer Hospital & Institute of Guangzhou Medical University

OTHER

collaborator

Zhongshan People's Hospital, Guangdong, China

OTHER

collaborator

Yuebei People's Hospital

OTHER

collaborator

Wuzhou Red Cross Hospital

OTHER

lead

Sun Yat-sen University

OTHER