Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial)

PHASE3RecruitingINTERVENTIONAL
Enrollment

662

Participants

Timeline

Start Date

February 16, 2022

Primary Completion Date

February 28, 2027

Study Completion Date

February 28, 2027

Conditions
Hematologic Neoplasms
Interventions
DRUG

Tranexamic Acid

"Patients allocated to the prophylactic Tranexamic Acid group will receive a standardized routine oral or intravenous dose of Tranexamic Acid 1 gram three times daily.~Tranexamic Acid will start when Platelet count is less than 50 x 109/L and continue until platelet engraftment. Patients in this group will not receive routine prophylactic platelet transfusions. Subjects unable to swallow oral Tranexamic Acid pills may have the tablets crushed, administered via nasogastric (NG) tube or the medication will be administered intravenously."

Trial Locations (11)

T2N4N2

RECRUITING

Tom Baker Cancer Centre, Calgary

Unknown

RECRUITING

Cross Cancer Institute, Edmonton

NOT_YET_RECRUITING

Memorial University, St. John's

NOT_YET_RECRUITING

Dalhousie University, Halifax

NOT_YET_RECRUITING

Hopital Maisonneuve-Rosemont, Montreal

RECRUITING

Saskatchewan Cancer Agency, Saskatoon

A1B 3V6

RECRUITING

Eastern Regional Health Authority, St. John's

L8V 1C3

RECRUITING

Hamilton Health Sciences - Juravinski Hospital and Cancer Centre, Hamilton

N6A5W9

RECRUITING

London Health Sciences Centre, London

K1H8L6

RECRUITING

The Ottawa Hospital, Ottawa

M5G 2M9

WITHDRAWN

Princess Margaret Cancer Centre, Toronto

All Listed Sponsors
collaborator

Alberta Cancer Foundation

OTHER

lead

Ottawa Hospital Research Institute

OTHER