NCT04448028View on ClinicalTrials.gov

Stop of Proton-pump Inhibitor Treatment in Patients With Liver Cirrhosis - a Double-blind, Placebo-controlled Trial

PHASE4RecruitingINTERVENTIONAL
Enrollment

476

Participants

Timeline

Start Date

April 22, 2021

Primary Completion Date

February 29, 2028

Study Completion Date

February 29, 2028

Conditions
Liver Cirrhosis
Interventions
DRUG

Placebo

Patients with a pre-existing PPI therapy discontinue PPI therapy and replace it with placebo over a period of 346 days after a 14 day dose tapering phase.

DRUG

Esomeprazole 20mg

Patients with a pre-existing PPI therapy stop their prior PPI medication and have it replaced with esomeprazole 20mg/day for 360 days.

Trial Locations (1)

20246

RECRUITING

University Medical Center Hamburg-Eppendorf, Hamburg

All Listed Sponsors
collaborator

German Federal Ministry of Education and Research

OTHER_GOV

collaborator

University Hospital Heidelberg

OTHER

lead

Universitätsklinikum Hamburg-Eppendorf

OTHER