EXPLORE: A Phase II Study to Evaluate the Safety and Efficacy of Two Doses of GT005

PHASE2TerminatedINTERVENTIONAL
Enrollment

98

Participants

Timeline

Start Date

April 26, 2019

Primary Completion Date

April 5, 2024

Study Completion Date

April 5, 2024

Conditions
Dry Age-related Macular Degeneration
Interventions
DRUG

GT005

GT005 is a recombinant, non-replicating AAV2 expressing human complement factor I (CFI). GT005 was administered as a single time subretinal injection into the study eye of subjects allocated to one of the two GT005 doses.

Trial Locations (55)

2000

Sydney Hospital and Sydney Eye Hospital, Sydney

10032

Columbia University Medical Center, New York

13008

Centre Paradis Monticelli, Marseille

14012

Hospital La Arruzafa, Córdoba

14620

Retina Associates of Western New York, Rochester

16507

Erie Retinal Surgery, INC, Erie

19107

Mid Atlantic Retina, Philadelphia

21079

CHU Hôpital F. Mitterrand, Dijon

21209

The Retina Care Center, Baltimore

23538

Universitaetsklinikum Schleswig-Holstein Campus Lübeck, Lübeck

26506

West Virginia University, Morgantown

28046

Clinica Baviera, Madrid

30909

Southeast Retina Center, Augusta

31008

Clinica Universidad de Navarra - Pamplona, Pamplona

32607

VitreoRetinal Associates, P.A., Gainesville

33136

Bascom Palmer Eye Institute, Miami

33711

Retina Vitreous Associates of Florida, St. Petersburg

37922

Southeastern Retina Associates, PC, Knoxville

38138

Charles Retina Institute, Memphis

40549

Internationale Innovative Ophthalmochirurgie, Düsseldorf

44000

CHU de Nantes - Hôtel-Dieu, Nantes

44195

Cleveland Clinic, Cleveland

45242

Cincinnati Eye Institute, Cincinnati

46100

Clinica Oftalvist Valencia, Valencia

46290

Midwest Eye Institute Northside, Indianapolis

48145

St. Franziskus-Hospital, Münster

50266

Wolfe Eye Clinic, West Des Moines

53127

Universitaetsklinikum Bonn, Bonn

55435

VitreoRetinal Surgery, PLLC, Minneapolis

60439

University Retina Macula Associates PC, Lemont

72076

Universitatsklinikum Tübingen, Tübingen

75231

Texas Retina Associates, Dallas

77401

Retina Consultants of Houston-TMC, Bellaire

78240

Retinal Consultants of San Antonio, San Antonio

78705

Austin Research Center for Retina, PLLC, Austin

85053

Retinal Research Institute (retina consultants of AZ), Phoenix

87109

Vision Research Center Eye Associates of New Mexico, Albuquerque

89502

Sierra Eye Associates, Reno

92064

Retina Consultants San Diego, Poway

92647

Retina Associates of Southern California, Huntington Beach

94303

Byers Eye Institute at Stanford, Palo Alto

97239

Casey Eye Institute, Portland

97401

Oregon Retina, Eugene

02114

Ophthalmic Consultants of Boston (OCB), Boston

98104-2499

Department of Ophthalmology UW Medicine, Seattle

Unknown

The University of Melbourne - The Centre for Eye Research Australia (CERA), Melbourne E.

6525 GA

Stichting Radboud Universitair Medisch Centrum, Nijmegen

85-631

Oftalmika Spolka z ograniczona odpowiedzialnoscia, Bydgoszcz

08195

Hospital Universitari General de Catalunya, Sant Cugat del Vallès

BS1 2LX

Bristol Eye Hospital, Bristol

L7 8XP

St.Paul's Eye Unit, Liverpool

EC1V 2PD

Moorfields Eye Hospital - NHS Foundation Trust, London

W1G 7LB

The Retina Clinic London, London

S10 2SB

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield

SR2 9HP

Sunderland Eye Infirmary, Sunderland

Sponsors
All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

lead

Gyroscope Therapeutics Limited

INDUSTRY