Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity

Systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.

Phenylephrine (0.0625 mcg/dL/min) will be locally infused via brachial artery catheter during the final 3 min of normoxia and hypoxia.

Dexmedetomidine (12.5 ng/dL/min) will be locally infused via brachial artery catheter during the final 3 min of normoxia and hypoxia.

Phentolamine will be locally infused via brachial artery catheter for 10 min before baseline measurement (12 mcg/dL/min) and the infusion will continue at a maintenance rate (5 mcg/dL/min) during acute normoxia and hypoxia.

Regional forearm infusion at 8 ng/dL/min via brachial artery catheter during normoxia and hypoxia exposures