204
Participants
Start Date
October 8, 2020
Primary Completion Date
November 16, 2022
Study Completion Date
September 30, 2027
Crovalimab
"Dosing depends on body weight. Participants will be dosed as follows:~* 5 kg to \< 12 kg: 100 mg IV on Week 1 Day 1 (W1D1); 85 mg SC on Week 1 Day 2 (W1D2) and Q2W from Week 3 until end of study~* 12 kg to \< 20 kg: 200 mg IV on W1D1; 85 mg SC on W1D2, Weeks 2, 3 and 4; 170 mg SC, Q2W from Week 5 until end of study~* 20 kg to \< 30 kg: 300 mg IV on W1D1; 85 mg SC on W1D2, Weeks 2, 3 and 4; 340 mg SC, Q4W from Week 5 until end of study~* 30 kg to \< 40 kg: 400 mg IV on W1D1; 170 mg SC on W1D2, Weeks 2, 3 and 4; 510 mg SC, Q4W from Week 5 until end of study~* 40 kg to \< 100 kg: 1000 mg IV on W1D1; 340 mg SC W1D2, Weeks 2, 3 and 4; 680 mg SC, Q4W from Week 5 until end of study~* 100 kg: 1500 mg IV on W1D1; 340 mg SC W1D2, Weeks 2, 3 and 4; 1020 mg SC, Q4W from Week 5 until end of study."
Eculizumab
Eculizumab will be administered as specified in the respective arm.
National Taiwan Universtiy Hospital, Taipei
Philippine General Hospital, Manila
St Lukes Medical Center, Quezon
Mary Mediatrix Medical Center, Lipa City
King Chulalongkorn Memorial Hospital, Pathum Wan
Siriraj Hospital, Bangkok
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City
Hospital General Universitario Gregorio Marañon, Madrid
Hospital Universitario Clinico San Carlos, Madrid
Hospital Universitario La Paz, Madrid
Hospital Raja Permaisuri Bainun, Ipoh
Hospital Universitario de Salamanca, Salamanca
Universitaetsklinkm, Essen
Hospital de Basurto, Bilbao
Maharaj Nakorn Chiang Mai Hospital, Chiang Mai
Ondokuz Mayis Univ. Med. Fac., Samsun
Hopital Claude Huriez - CHU Lille, Lille
Global Trial Research Center S.A. de C.V., Monterrey
Hospital Ampang, Ampang
Centre Hospitalier Lyon Sud, Pierre-Bénite
Universitaetsklinikum Ulm, Ulm
Peking Union Medical College Hospital, Beijing
National University Hospital, Singapore
Singapore General Hospital, Singapore
Huashan Hospital, Fudan University, Shanghai
Spitalul Clinic Municipal Filantropia Craiova, Craiova
Jiangsu Province Hospital, Nanjing
Affiliated Hospital of Nantong University, Nantong
The First Affiliated Hospital, Zhejiang University, Hangzhou
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan
Nanfang Hospital, Southern Medical University, Guangzhou
Organizacion Medica de Investigacion (OMI), Ciudad Autonoma Buenos Aires
Centro Integrado de Oncologia de Curitiba, Curitiba
*X*CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia, Santo André
Beneficencia Portuguesa de Sao Paulo, São Paulo
General Hospital of Thessaloniki G. Papanikolaou, Thessaloniki
Sapporo Medical University Hospital, Hokkaido
University of Tsukuba Hospital, Ibaraki
NTT Medical Center Tokyo, Tokyo
Amsterdam UMC, Locatie AMC, Amsterdam
Szpital Uniwersytecki nr2 im. dr J. Biziela, Bydgoszcz
Samodzielny Publiczny Szpital Kliniczny nr 1, Lublin
Pratia Poznan, Skórzewo
MTZ Clinical Research Powered by Pratia, Warsaw
Instituto Portugues Oncologia de Lisboa Francisco Gentil EPE, Lisbon
Spitalul Universitar de Urgenta Bucuresti, Bucharest
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
ICO Badalona - Hospital Universitari Germans Trias i Pujol, Badalona
Hospital Clinic de Barcelona, Barcelona
Chang Gung Medical Foundation - Kaohsiung, Kaohisung
Medical Center OK!Clinic+, Kyiv
St James University Hospital, Leeds
Kings College Hospital, London
Collaborators (1)
Chugai Pharmaceutical
INDUSTRY
Hoffmann-La Roche
INDUSTRY