33
Participants
Start Date
August 11, 2020
Primary Completion Date
June 30, 2025
Study Completion Date
June 30, 2025
Entry of demographic and medical history data into a deidentified database
Entry into repository for analysis.
Blood sample for DNA analysis
Targeted resequencing of DNA to identify variants associated with hypoglycemia, comparing participants with hypoglycemia (both surgical and non-surgical) and healthy controls.
Stool sample for microbiome analysis
Participants will be asked to provide a fecal sample, collected at home, which will be analyzed to determine the types of bacteria present in the feces.
Mixed meal tolerance test
For a subset of participants: After an overnight fast, participants will be given a standard liquid mixed meal; blood samples will be collected at baseline (fasting) and at defined time points after a meal for metabolic and hormonal analyses.
Continuous glucose monitoring
A CGM sensor (Dexcom G4 or other professional version available at onset of study) will be placed in blinded (masked) mode, and will be worn for 10 days. Data will be analyzed to determine patterns of glucose during both day and night intervals.
activity monitor
The activity monitor (Fitbit Charge 2) will be worn by participants for 10 days, to assess activity, concurrent with CGM sensor wear.
Joslin Diabetes Center, Boston
Joslin Diabetes Center
OTHER