56
Participants
Start Date
August 18, 2020
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2025
ICE [ifosfamide+carboplatin+etoposide]
"• Combined with ICE chemotherapy regimen:~* Ifosfamide: 5 g/m2, continuous intravenous (iv) infusion (mesna 5 g/m2 synchronously iv infusion for rescue), on Day 2;~* Carboplatin: with concentration-area under time curve (AUC)=5 (highest concentration to 800 mg), iv infusion, on Day 2;~* Etoposide l00 mg/m2, iv infusion, on Days 1-3;~* ATG-010 60 mg/once, oral, on Days 4 and 11. After the treatment with combination chemotherapy, the patients will continue to receive maintenance treatment of ATG-010 60 mg/once per week (QW)."
GEMOX [gemcitabine+oxaliplatin]
"• Combined with GEMOX chemotherapy regimen:~* Gemcitabine 1000 mg/m2, iv infusion, on Days 1 and 8;~* Oxaliplatin 130 mg/m2, iv infusion, on Day 1;~* ATG-010 60 mg/once, oral, on Days 2 and 9. After the treatment with combination chemotherapy, the patients will continue to receive maintenance treatment of ATG-010 60 mg/once per week (QW)."
Tislelizumab
Tislelizumab will be administered intravenously at a fixed dose of 2 0 0 mg every 3 weeks on Day 1 of each cycle
Beijing Tongren Hospital.CMU, Beijing
Peking University Third Hospital, Beijing
Fudan University Shanghai Cancer Center, Shanghai
Jiangsu Cancer Hospital, Nanjing
Jiangsu Province Hospital, Nanjing
Anhui Provincial Cancer Hospital, Hefei
Tianjin Medical Universisity Cancer Institute & Hospital, Tianjin
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou
Chongqing University Cancer Hospital, Chongqing
Hubei Cancer Hospital, Wuhan
Henan Cancer Hospital, Zhengzhou
Sun Yat-sen University Cancer Center, Guangzhou
Guangxi Medical University Cancer Hospital, Nanning
Antengene Corporation
INDUSTRY