MARGetuximab Or Trastuzumab (MARGOT)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

174

Participants

Timeline

Start Date

July 13, 2020

Primary Completion Date

October 24, 2024

Study Completion Date

July 1, 2027

Conditions
Breast CancerStage II Breast CancerStage III Breast CancerHER2-positive Breast Cancer
Interventions
DRUG

Paclitaxel

Pre-determined dose administered via IV, Day 1,8,15 of each cycle 4 study cycles, or 12 weeks.

DRUG

Pertuzumab

Pre-determined dose administered via IV - Day 1 of each 21- day cycle 4 study cycles, or 12 weeks.

DRUG

Margetuximab

Pre-determined dose administered by IV - Day 1 of each 21- day cycle 4 study cycles, or 12 weeks.

DRUG

Trastuzumab

Pre-determined dose administered via IV Day 1 of each 21- day cycle for 4 study cycles, or 12 weeks.

Trial Locations (14)

10461

Montefiore Medical Center, The Bronx

15213

University of Pittsburgh Medical Center, Pittsburgh

15601

UPMC Hillman Cancer Center - Arnold Palmer at Mountain View, Greensburg

15642

UPMC Hillman Cancer Center - Arnold Palmer at Norwin, Irwin

20007

Georgetown University Medical Center, Washington D.C.

20010

MedStar Washington Hospital Center, Washington D.C.

77030

Baylor College of Medicine Medical Center, Houston

MD Anderson Cancer Center, Houston

98109

University of Washington Fred Hutchinson Cancer Care, Seattle

02215

Beth Israel Deaconess Medical Center, Boston

Dana Farber Cancer Institute, Boston

02035

Dana-Farber Brigham Cancer Center - Foxborough, Foxborough

01757

Dana-Farber at Milford, Milford

02190

Dana-Farber at South Shore Hospital, Weymouth

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

MacroGenics

INDUSTRY

collaborator

Translational Breast Cancer Research Consortium

OTHER

lead

Dana-Farber Cancer Institute

OTHER