Vascular Endothelial Growth Factor-B (VEGF-B) Blockade With the Monoclonal Antibody CSL346 in Subjects With Diabetic Kidney Disease

PHASE2CompletedINTERVENTIONAL
Enrollment

114

Participants

Timeline

Start Date

September 14, 2020

Primary Completion Date

October 24, 2022

Study Completion Date

October 24, 2022

Conditions
Diabetic Kidney Disease (DKD)
Interventions
BIOLOGICAL

CSL346

VEGF-B antagonist monoclonal antibody

DRUG

Placebo

Normal saline

Trial Locations (37)

2025

Middlemore Hospital, Auckland

2291

Hunter Diabetes Centre - The AIM Centre, Merewether

3021

Sunshine Hospital, St Albans

3052

The Royal Melbourne Hospital, Parkville

3065

St Vincent's Hospital, Fitzroy

3084

The Austin Hospital, Heidelberg

5112

Lyell McEwin Hospital, Elizabeth Vale

6140

Endocrine Associates - Wellington, Wellington

8011

Christchurch Hospital, Christchurch

Lipid and Diabetes Research Group, Christchurch

10301

Center for Thyroid & Parathyroid Disorders, Staten Island

27834

Physicians East, P.A. - Endocrinology, Greenville

34761

West Orange Endocrinology, Ocoee

37232

Vanderbilt University School of Medicine, Nashville

64239

3760044 - Tel Aviv Sourasky Medical Center, Tel Aviv

65212

University of Missouri Health System, Columbia

70006

Omega Clinical Research, Metairie

76100

3760045 - Kaplan Medical Center, Rehovot

77040

Juno Research, L.L.C., Houston

77079

The Endocrine Center, Houston

78215

Renal Associates, P.A. - San Antonio, San Antonio

78224

Primary Care Providers of Texas, San Antonio

78231

Diabetes and Metabolism Specialists (DMS) - San Antonio, San Antonio

89148

Palm Medical Group, LLC - Las Vegas, Las Vegas

90260

Renal Medical Associate/NARI, Lynwood

90717

Torrance Clinical Research (TCR) - Lomita, Lomita

91324

Amicis Research Center, Northridge

California Medical Research Associates, Inc, Northridge

91702

California Kidney Specialists (CKS) - Citrus Office, Covina

92503

Riverside Nephrology Group, Riverside

93720

Valley Research - Fresno, Fresno

96814

East-West Medical Research Institute, Honolulu

02111

Tufts Medical Center, Boston

01107

Renal and Transplant Associates, Springfield

M5G 2N2

1240130 - University Health Network, Toronto

00927

Fundación de Investigación, San Juan

00935

University of Puerto Rico - Puerto Rico Clinical and TRC, San Juan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

CSL Behring

INDUSTRY

NCT04419467 - Vascular Endothelial Growth Factor-B (VEGF-B) Blockade With the Monoclonal Antibody CSL346 in Subjects With Diabetic Kidney Disease | Biotech Hunter | Biotech Hunter