Study of Efficacy and Safety of LXH254 Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

134

Participants

Timeline

Start Date

October 30, 2020

Primary Completion Date

March 27, 2026

Study Completion Date

March 27, 2026

Conditions
Melanoma
Interventions
DRUG

LXH254

LXH254 will be supplied as tablet for oral use.

DRUG

LTT462

LTT462 will be supplied as hard gelatin capsule for oral use.

DRUG

Trametinib

Trametinib will be supplied as film-coated tablet for oral use

DRUG

Ribociclib

Ribociclib will be supplied in tablets and hard gelatin capsules.

Trial Locations (36)

1011

Novartis Investigative Site, Lausanne

2060

Novartis Investigative Site, North Sydney

2610

Novartis Investigative Site, Wilrijk

3000

Novartis Investigative Site, Leuven

4102

Novartis Investigative Site, Wooloongabba

6008

Novartis Investigative Site, Subiaco

8091

Novartis Investigative Site, Zurich

10016

NYU Laura and Isaac Perlmutter Cancer Center, New York

10017

Memorial Sloan Kettering, New York

13885

Novartis Investigative Site, Marseille

15213

University of Pittsburgh Med Center, Pittsburgh

20133

Novartis Investigative Site, Milan

31059

Novartis Investigative Site, Toulouse

33612

H Lee Moffitt Cancer Center and Research Institute, Tampa

33901

Florida Cancer Specialists, Fort Myers

45147

Novartis Investigative Site, Essen

55905

Mayo Clinic Mayo Rochester, Rochester

Mayo Clinic Rochester, Rochester

59037

Novartis Investigative Site, Lille

69120

Novartis Investigative Site, Heidelberg

69495

Novartis Investigative Site, Pierre-Bénite

72076

Novartis Investigative Site, Tübingen

75475

Novartis Investigative Site, Paris

77030

Univ of TX MD Anderson Cancer Cntr, Houston

80131

Novartis Investigative Site, Napoli

90025

The Angeles Clinic and Research Institute, Los Angeles

94143

UCSF Medical Center, San Francisco

94800

Novartis Investigative Site, Villejuif

5265601

Novartis Investigative Site, Ramat Gan

02114

Massachusetts General Hospital, Boston

02215

Dana Farber Cancer Institute, Boston

C1426ANZ

Novartis Investigative Site, CABA

01307

Novartis Investigative Site, Dresden

6229 HX

Novartis Investigative Site, Maastricht

0310

Novartis Investigative Site, Oslo

M20 2BX

Novartis Investigative Site, Manchester

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY