A Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Placebo in Hospitalized Participants With Severe COVID-19 Pneumonia

PHASE3CompletedINTERVENTIONAL
Enrollment

649

Participants

Timeline

Start Date

June 16, 2020

Primary Completion Date

February 1, 2021

Study Completion Date

March 8, 2021

Conditions
COVID-19 Pneumonia
Interventions
DRUG

Remdesivir

Participants will receive intravenous (IV) RDV

DRUG

Tocilizumab

Participants will receive IV TCZ

DRUG

Placebo

Participants will receive IV placebo matched to TCZ

Trial Locations (54)

11237

Wyckoff Heights Medical Center, Staten Island

18103

Lehigh Valley Hospital, Allentown

19002

Hospital General Universitario de Guadalajara, Guadalajara

19107

Thomas Jefferson University, Philadelphia

20007

Medstar Georgetown University Hospital, Washington D.C.

21201

University of Maryland, Baltimore

26506

West Virginia University Hospital, Morgantown

28005

Hospital Universitario Principe de Asturias; Medicina Interna - Servicio de Enfermedades Infecciosas, Alcalá de Henares

28040

Hospital Universitario Fundacion Jimenez Diaz., Madrid

28204

Novant Health Clinical Research, Charlotte

28250

Hospital Universitario HM Torrelodones, Torrelodones

29425

Medical University of South Carolina, Charleston

33012

Larkin Community Hospital Palm Springs Campus (Hialeah), Hialeah

33136

University of Miami Miller School of Medicine; Clinical Reseach Building, Miami

33143

Larkin Community Hospital, South Miami

33308

Holy Cross Hospital Inc, Fort Lauderdale

43214

OhioHealth Research Institute, Columbus

48322

Henry Ford Medical Center, Novi

60453

Advocate Christ Medical Center, Oak Lawn

70121

Ochsner Clinic Foundation, New Orleans

75061

Baylor Scott & White Medical Center - Irving, Irving

75093

Baylor Scott & White Hospital - Plano, Plano

75231

Baylor University Medical Center, Dallas

76012

The Liver Institute at Methodist Dallas, Arlington

76502

Baylor Scott & White Health, Temple

77030

Baylor St. Luke's Medical Center, Houston

Ben Taub General Hospital - HCHD, Houston

Houston Methodist Hospital, Houston

77845

Baylor Scott and White Medical Center - College Station, College Station

83702

St Luke's Health System; Rheumatology Research, Boise

84143

Intermountain LDS Hospital, Salt Lake City

85008

Valleywise Health Medical Center, Phoenix

87401

San Juan Oncology Associates, Farmington

90404

Providence St Johns Health Center, Santa Monica

91911

eStudySite - Chula Vista - PPDS, Chula Vista

92612

Hoag Hospital Irvine, Irvine

97225

Providence Saint Vincent's Medical Center, Portland

98201

The Providence Regional Medical Center Everett, Everett

111539

O.M. Filatov City Clinical Hospital #15; Department of Surgery, Moskva

123182

City Clinical Hospital # 52, Moscow

143442

Medsi Clinic, Moscow

199106

City Pokrovskaya Hospital, Saint Petersburg

06501

Yale University School of Medicine; HIV Clinical Trials Program, New Haven

02118-2393

Boston Medical Center, Boston

01199

Baystate Medical Center, Springfield

07102

St. Michael'S Medical Center, Newark

30150-221

Santa Casa de Misericordia de Belo Horizonte, Belo Horizonte

80810-040

Hospital Nossa Senhora das Graças; Setor de Pesquisa em Neurologia, Curitiba

21045-900

Instituto de Pesquisa Clinica Evandro Chagas - IPEC FIOCRUZ, Rio de Janeiro

09715-090

CEMEC - Centro Multidisciplinar de Estudos Clínicos, São Bernardo do Campo

15090-000

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

01246-000

Instituto de Infectologia Emilio Ribas, São Paulo

05403-900

Instituto do Coração - HCFMUSP, São Paulo

08907

Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Gilead Sciences

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY