A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

153

Participants

Timeline

Start Date

June 3, 2020

Primary Completion Date

June 30, 2029

Study Completion Date

June 30, 2029

Conditions
Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia
Interventions
BIOLOGICAL

AUTO1

Following pre-conditioning with chemotherapy (cyclophosphamide and fludarabine) patients will be treated with a total target dose of 410E+6 of CD19-positive CAR T cells as a split dose on Day 1 and on Day 10 (±2 days).

Trial Locations (34)

10065

Memorial Sloan Kettering Cancer Center, New York

14642

University of Rochester, Rochester

21201

University of Maryland Medical Center, Baltimore

30322

Winship Cancer Institute of Emory University, Atlanta

33136

University of Miami, Miami

33612

H Lee Moffitt Cancer Center, Tampa

37203

TriStar Centennial Medical Center (SCRI), Nashville

41013

Hospital Universitario Virgen del Rocío, Seville

44195

Cleveland Clinic, Cleveland

46026

Hospital Universitario La Fé, Valencia

53226

The Medical College of Wisconsin, Milwaukee

55905

Mayo Clinic, Rochester

60637

University of Chicago, Chicago

63110

Washington University School of Medicine, St Louis

66160

University of Kansas, Kansas City

68105

University of Nebraska, Omaha

75246

Baylor Scott & White Research Institute, Dallas

77030

MD Anderson Cancer Center, Houston

78229

TTI-Methodist (Texas Transplant Institute) (SCRI), San Antonio

80218

Colorado Blood Cancer Institute (CBCI), Denver

92093

University of California San Diego Health (UCSD), La Jolla

93534

City of Hope National Medical Center, Duarte

94143

University of California San Francisco (UCSF), San Francisco

95817

University of California Davis (UC Davis), Sacramento

02115

Dana-Farber Cancer Institute, Boston

08035

Fundacio' Hospital Universitari Vall d'Hebron, Barcelona

CB2 0QQ

Cambridge University Hospitals NHS Foundation Trust, Cambridge

NW1 2PG

University College London Hospitals NHS Foundation Trust, London

SE5 9RS

King's College Hospital, London

M13 9WL

Manchester Royal Infirmary Hospital, Manchester

G514TF

Queen Elizabeth University Hospital, Glasgow

NE7 7DN

Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

B15 2GW

University Hospitals Birmingham NHS Foundation Trust, Birmingham

BS2 8ED

University Hospitals Bristol and Weston NHS Foundation Trust (UHBW), Bristol

All Listed Sponsors
lead

Autolus Limited

INDUSTRY