"Hydroxychloroquine and Lopinavir/ Ritonavir to Improve the Health of People With COVID-19: The Hope Coalition - 1"

PHASE3UnknownINTERVENTIONAL
Enrollment

1,968

Participants

Timeline

Start Date

June 3, 2020

Primary Completion Date

February 1, 2021

Study Completion Date

February 1, 2021

Conditions
COVID-19Coronavirus InfectionVirus DiseaseAcute Respiratory InfectionSARS-CoV Infection
Interventions
DRUG

Hydroxychloroquine Sulfate Tablets

Tablets of 400 mg: Loading dose of 02 tablets followed by one tablet of 400 mg orally on the following 09 days

DRUG

Lopinavir/ Ritonavir Oral Tablet

tablets of 200/ 50 mg; Loading dose of 04 tablets twice a day on day 1 followed by two tablets twice a day on the following 09 days

DRUG

Hydroxychloroquine Sulfate Tablets plus Lopinavir/ Ritonavir Oral Tablets

"Hydroxychloroquine Oral Tablet 400 mg: Loading dose of 02 tablets followed by one tablet of 400 mg orally on the following 09 days~plus~Lopinavir/ Ritonavir Oral Tablet of 200/ 50 mg: Loading dose of 04 tablets twice a day on day 1 followed by two tablets twice a day on the following 09 days"

DRUG

Placebo

Placebo tablets - 01 tablet twice daily from day 01 through day 10.

Trial Locations (4)

30150240

RECRUITING

CARDRESEARCH - Cardiologia Assistencial e de Pesquisa, Belo Horizonte

30535901

NOT_YET_RECRUITING

Pontificia Universidade Catolica de Minas Gerais, Belo Horizonte

32600412

RECRUITING

Fundo Municipal de Saúde de Betim, Betim

35400000

NOT_YET_RECRUITING

Universidade Federal de Ouro Preto, Ouro Preto

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Cardresearch - Cardiologia Assistencial e de Pesquisa LTDA

UNKNOWN

collaborator

Cytel Inc.

INDUSTRY

lead

Cardresearch

OTHER