Anti-SARS Cov-2 T Cell Infusions for COVID 19

PHASE1TerminatedINTERVENTIONAL
Enrollment

4

Participants

Timeline

Start Date

November 4, 2020

Primary Completion Date

October 12, 2021

Study Completion Date

October 12, 2021

Conditions
SARS-CoV 2Viral InfectionCOVID 19
Interventions
BIOLOGICAL

Dose Finding Phase (MTD)

Enrollment to the dose escalation phase will be staggered. The first patient enrolled on each of the 3 dose levels (DL1, DL2 and DL3) will have to complete the 14-day toxicity monitoring window prior to enrollment of the next patients. Prior to dose escalation, all patients at a particular dose level should have completed the minimum 14-day toxicity monitoring window before enrolling to a higher dose level.

BIOLOGICAL

Partially HLA-matched SARS-CoVSTs

Infusion of SARS-CoVSTs at the MTD level as determined in the Dose Finding Phase

OTHER

Routine care (no SARS-CoVSTs)

Patients receive routine care for COVID19 per institutional standards (including antivirals such as remdesivir or other FDA-EUA approved products and thromboprophylaxis).

Trial Locations (1)

77030

Houston Methodist Hospital, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Center for Cell and Gene Therapy, Baylor College of Medicine

OTHER

collaborator

AlloVir

INDUSTRY

collaborator

The Methodist Hospital Research Institute

OTHER

lead

Baylor College of Medicine

OTHER