Tocilizumab for the Prevention of Graft Failure and GVHD in Haplo-Cord Transplantation

Tocilizumab 8 mg/kg intravenously administered as a single dose on Day -1 of transplant conditioning regimen

Fludarabine 30 mg/m2 intravenously administered on Day -7, Day -6, Day -5, Day -4, Day -3 of transplant conditioning regimen if under the age of 60. If over the age of 60, Fludarabine 30 mg/m2 intravenously administered on Day -5, Day -4 and Day -3 of transplant conditioning regimen.

Melphalan 140 mg/m2 intravenously administered on Day -2 of transplant conditioning regimen.

Anti-thymocyte globulin (ATG) 1.5 mg/kg

Total Body Irradiation (TBI) 2 Gray, administered on Day -4 and Day -3 of transplant conditioning regimen