Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial Fibrillation

NAUnknownINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

March 7, 2022

Primary Completion Date

March 31, 2024

Study Completion Date

April 30, 2024

Conditions
Atrial Fibrillation
Interventions
DRUG

Amiodarone

"Patients will undergo one of the two regimens of amiodarone, based on their ability to tolerate po (per os) intake in the post-operative period:~• All patient will receive 1050mg of amiodarone in 100mL of 5% dextrose administered intravenously initiated at the time of anesthesia induction at a rate of 0.73mg/min or 43.75mg/h and continued over 24 hours followed by:~* If able to tolerate po intake: 400mg po BID for post-operative days 1 to 5 or until the day of discharge (whichever occurs first).~* If unable to tolerate po intake: daily infusion of 1050mg in 100mL of 5% dextrose for postoperative days 1 to 5 or until the day of discharge (whichever occurs first)."

DRUG

Placebo

"Patients will undergo one of the two schedules or intravenous infusion, based on their ability to tolerate po intake in the post-operative period:~* All patients will receive 100mL of 5% dextrose administered intravenously initiated at the time of anesthesia induction at a rate of 0.73mg/min or 43.75mg/h and continued over 24 hours followed by:~ o If able to tolerate po intake: 400mg po BID for post-operative days 1 to 5 or until the day of discharge (whichever occurs first).~* Esophagectomy patient will receive 100mL of 5% dextrose at the time of anesthesia induction at a rate of what would be 0.73mg/min or 43.75mg/h if it contained 1050mg of amiodarone, followed by daily infusion of 100mL of 5% dextrose for 4 days or until the day of discharge (whichever occurs first)."

Trial Locations (1)

K1H 8L6

RECRUITING

The Ottawa Hospital, Ottawa

All Listed Sponsors
lead

Ottawa Hospital Research Institute

OTHER