COVID-19 and Anti-CD14 Treatment Trial

PHASE2TerminatedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

April 12, 2021

Primary Completion Date

February 4, 2022

Study Completion Date

February 4, 2022

Conditions
Coronavirus Disease 2019 (COVID-19)Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Interventions
BIOLOGICAL

anti-CD14

4 mg/kg on Day 1, 2 mg/kg on Days 2-4 administered intravenously (IV)

OTHER

Placebo

Placebo administered intravenously on Days 1-4

DRUG

remdesivir

Remdesivir administered intravenously for 5 days beginning with a 200 mg loading dose on Day 1, followed by 100 mg/day on Days 2-5.

Trial Locations (5)

34236

Sarasota Memorial Health Care System, Sarasota

98101

Virginia Mason Medical Center, Seattle

98104

Harborview Medical Center, Seattle

98122

Swedish Medical Center, Seattle

98195

University of Washington Medical Center-Montlake, Seattle

All Listed Sponsors
collaborator

University of Washington

OTHER

collaborator

Implicit Bioscience

INDUSTRY

collaborator

Vanderbilt University Medical Center

OTHER

collaborator

PPD Development, LP

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH