A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia

PHASE2CompletedINTERVENTIONAL
Enrollment

396

Participants

Timeline

Start Date

June 2, 2020

Primary Completion Date

January 8, 2021

Study Completion Date

February 12, 2021

Conditions
COVID-19 Pneumonia
Interventions
DRUG

MSTT1041A

Participants received one intravenous (IV) infusion of MSTT1041A 700 milligrams (mg) on Day 1. A second IV dose of MSTT1041A 350 mg was given on Day 15 if the participant remained hospitalized with a requirement for supplemental oxygen.

DRUG

MSTT1041A-matched Placebo

Participants received up to 2 intravenous infusions of MSTT1041A-matched placebo.

DRUG

UTTR1147A

Participants received one intravenous (IV) infusion of UTTR1147A 90 micrograms/kilogram body weight (μg/kg) on Day 1. A second IV dose of UTTR1147A 90 μg/kg was given on Day 15 if the participant remained hospitalized with a requirement for supplemental oxygen.

DRUG

UTTR1147A-matched Placebo

Participants received up to 2 intravenous infusions of UTTR1147A-matched placebo.

Trial Locations (41)

10305

Staten Island University Hospital; Department of Pharmacy, Staten Island

10451

Lincoln Medical Mental Health Center, The Bronx

12208

Albany Medical Center, Albany

18103

Lehigh Valley Health Network, Allentown

19002

Hospital General Universitario de Guadalajara, Guadalajara

22320

Hospital General de Tijuana, Tijuana

23292

Virginia Commonwealth University, Richmond

29603

Hospital Costa del Sol; Servicio de Oncologia, Marbella

30060

WellStar Research Institute, Marietta

33744

Bay Pines VA Medical Center - NAVREF, Bay Pines

37007

Complejo Asistencial Universitario de Salamanca - H. Clinico, Salamanca

43608

Mercy St. Vincent Medical Center, Toledo

44340

Nuevo Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara

47005

Hospital Clinico Universitario Valladolid, Valladolid

48202

Henry Ford Health System, Detroit

70006

MedPharmics, Metairie

70112

Southeast Louisiana Veterans Health Care System - NAVREF, New Orleans

71301

DM Clinical Research - Alexandria Cardiology Clinic - ERN - PPDS, Alexandria

72205

University of Arkansas For Medical Sciences, Little Rock

75235

Parkland Health & Hospital System, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

80204

Denver Health Medical Center, Denver

87401

San Juan Oncology Associates, Farmington

90505

Torrance Memorial Medical Center, Torrance

91911

eStudySite - Chula Vista - PPDS, Chula Vista

91942

eStudySite, La Mesa

97213

Providence Portland Medical Center; Investigational Drug Services/Regional Research, Portland

98101

Virginia Mason Medical Center, Seattle

98405

MultiCare Institute for Research and Innovation; Clinic/Outpatient Facility, Tacoma

07503

St. Joseph'S Regional Medical Center, Paterson

21040-360

Instituto de Pesquisa Clinica Evandro Chagas FIOCRUZ, Rio de Janeiro

90020-090

Santa Casa de Porto Alegre, Porto Alegre

13060-904

Hospital E Maternidade Celso Pierro PUCCAMP, Campinas

15090-000

Hospital de Base Da Faculdade de Medicina de Sao Jose Do Rio Preto, São José do Rio Preto

01323-903

Hospital Alemao Oswaldo Cruz, São Paulo

05403-900

Instituto do Coração - HCFMUSP, São Paulo

Unknown

Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, México

Instituto Nacional De Enfermedades Respiratorias INER National Institute of Respiratory Diseases, México

08907

Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat

08003

Hospital del Mar, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Biomedical Advanced Research and Development Authority

FED

lead

Genentech, Inc.

INDUSTRY