Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

173

Participants

Timeline

Start Date

July 7, 2020

Primary Completion Date

August 30, 2024

Study Completion Date

August 30, 2024

Conditions
Prostatic Neoplasms, Castration-ResistantAndrogen-Resistant Prostatic NeoplasmsCastration Resistant Prostatic NeoplasmsProstatic Cancer, Castration-Resistant
Interventions
DRUG

Etrumadenant

Etrumadenant is an A2aR and A2bR antagonist

DRUG

Zimberelimab

Zimberelimab is an anti-PD-1 antibody

DRUG

Quemliclustat

Quemliclustat is a Cluster of Differentiation (CD)73 Inhibitor.

DRUG

Enzalutamide

Enzalutamide is an androgen receptor inhibitor

DRUG

Docetaxel

Docetaxel is type of chemotherapy

DRUG

SG

Sacituzumab govitecan is an antibody-drug conjugate

Trial Locations (19)

14642

Wilmot Cancer Institute Oncology, University of Rochester, Rochester

21287

Johns Hopkins University, Baltimore

32308

Florida Cancer Specialists Panhandle, Tallahassee

33401

Florida Cancer Specialists East, West Palm Beach

33705

Florida Cancer Specialists North, St. Petersburg

34232

Florida Cancer Specialists South, Sarasota

37203

Tennessee Oncology - Nashville, Nashville

37404

Tennessee Oncology - Chattanooga, Chattanooga

44195

Cleveland Clinic, Cleveland

60521

Affinity Health Hope & Healing Cancer Services, Hinsdale

60611

Northwestern University Feinberg School of Medicine, Chicago

77030

MD Anderson Cancer Center, Houston

90703

The Oncology Institute of Hope & Innovation, Cerritos

91436

The University of California, Los Angeles, Encino

92868

The University of California, Irvine Medical Center, Orange

99208

Medical Oncology Associates, PS (dba Summit Cancer Centers), Spokane

01006

New York University, Langone Health, New York

L8V5C2

Juravinski Cancer Center, Hamilton

H2X 3E4

Centre hospitalier de l'Université de Montréal (CHUM) Centre de Recherche, Montreal

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Gilead Sciences

INDUSTRY

lead

Arcus Biosciences, Inc.

INDUSTRY

NCT04381832 - Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate Cancer | Biotech Hunter | Biotech Hunter