SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

July 22, 2021

Primary Completion Date

June 5, 2024

Study Completion Date

June 5, 2024

Conditions
Alzheimer Disease
Interventions
DRUG

Pepinemab

Pepinemab is a humanized IgG4 monoclonal antibody. The antibody is formulated at 20 mg/mL in 20 mM Sodium Acetate buffer, pH 5.4, containing 130 mM Sodium Chloride and 0.02% Polysorbate 80

DRUG

Placebo

Placebo consists of formulation buffer only which is 20 mM Sodium Acetate buffer, pH 5.4, containing 130 mM Sodium Chloride and 0.02% Polysorbate 80

Trial Locations (14)

10032

Columbia University Irving Medical Center, New York

12212

Neurological Associates of Albany, Albany

14226

Dent Neurological Associates, Amherst

14620

University of Rochester Medical Center, Rochester

20057

Georgetown University, Washington D.C.

22031

Re-Cognition Health, Fairfax

33445

Brain Matters Research, Delray Beach

33462

JEM Research Institute, Lake Worth

33480

Premiere Research Institute of Palm Beach, Neurology, Palm Beach

33912

Neuropsychiatric Research Center of Southwest Florida, Fort Myers

34997

Brain Matters Research, Stuart

46202

Indiana University School of Medicine, Indianapolis

66205

University of Kansas Medical Center, Fairway

92103

Pacific Research Network, Inc, San Diego

All Listed Sponsors
collaborator

Alzheimer's Drug Discovery Foundation

OTHER

collaborator

Alzheimer's Association

OTHER

lead

Vaccinex Inc.

INDUSTRY

NCT04381468 - SEMA4D Blockade Safety and Brain Metabolic Activity in Alzheimer's Disease (AD) | Biotech Hunter | Biotech Hunter