Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

March 30, 2022

Primary Completion Date

May 31, 2027

Study Completion Date

June 30, 2028

Conditions
Graft Vs Host Disease
Interventions
DRUG

Placebo

During the extended dosing of abatacept, those randomized to receive 4 doses will receive a placebo consisting of an equal volume of normal saline solution.

DRUG

Abatacept

Investigational prophylaxis with extended-dosing abatacept, a calcineurin inhibitor and methotrexate.

Trial Locations (14)

14642

University of Rochester, Rochester

19104

Children's Hospital of Philadelphia, Philadelphia

30322

Emory University/Winship Cancer Center, Atlanta

33612

Moffitt Cancer Center, Tampa

45229

Cincinnati Children's Hospital, Cincinnati

48109

University of Michigan, Ann Arbor

60637

University of Chicago, Chicago

63110

Washington University St. Louis, St Louis

91010

City Of Hope National Medical Center, Duarte

97239

Oregon Health and Sciences University, Portland

02114

Massachusetts General Hospital, Boston

02115

Boston Children's Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Boston Children's Hospital

OTHER

NCT04380740 - Extended vs Short-term Abatacept Dosing for Graft Versus Host Disease Prophylaxis | Biotech Hunter | Biotech Hunter