NCT04376684 - Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease | Biotech Hunter

Enrollment

1,156

Participants

Timeline

Start Date

May 28, 2020

Primary Completion Date

July 15, 2021

Study Completion Date

August 16, 2021

Conditions

Severe Acute Respiratory Syndrome

Interventions

BIOLOGICAL

Otilimab

Otilimab will be administered once via IV route.

BIOLOGICAL

Placebo 1

Placebo 1 will consist of sterile 0.9 percent (%) sodium chloride solution administered once via IV route.

BIOLOGICAL

Placebo 2

Placebo 2 will consist of sterile 5% dextrose or 5% glucose solution administered once via IV route.

DRUG

Standard of care

All participants will receive standard of care as per institutional protocol.

Trial Locations (120)

1090

GSK Investigational Site, Brussels

1501

GSK Investigational Site, Benoni

1605

GSK Investigational Site, Munro

1842

GSK Investigational Site, Buenos Aires

2193

GSK Investigational Site, Johannesburg

4052

GSK Investigational Site, Durban

5000

GSK Investigational Site, Córdoba

5530

GSK Investigational Site, Yvoir

6850

GSK Investigational Site, Worcester

7500

GSK Investigational Site, Panorama

7505

GSK Investigational Site, Tygerberg

14000

GSK Investigational Site, México

14080

GSK Investigational Site, Mexico City

18901

GSK Investigational Site, Doylestown

19140

GSK Investigational Site, Philadelphia

20876

GSK Investigational Site, Germantown

20910

GSK Investigational Site, Silver Spring

21201

GSK Investigational Site, Baltimore

24017

GSK Investigational Site, Roanoke

26006

GSK Investigational Site, Logroño

28006

GSK Investigational Site, Madrid

28007

GSK Investigational Site, Madrid

28040

GSK Investigational Site, Madrid

28055

GSK Investigational Site, Madrid

28203

GSK Investigational Site, Charlotte

28702

GSK Investigational Site, San Sebastián de Los Reyes/Madrid

32608

GSK Investigational Site, Gainesville

36608

GSK Investigational Site, Mobile

38700

GSK Investigational Site, La Tronche

39216

GSK Investigational Site, Jackson

43608

GSK Investigational Site, Toledo

44280

GSK Investigational Site, Guadalajara

49933

GSK Investigational Site, Angers

53295

GSK Investigational Site, Milwaukee

55101

GSK Investigational Site, Saint Paul

55426

GSK Investigational Site, Saint Louis Park

59322

GSK Investigational Site, Valenciennes

60190

GSK Investigational Site, Winfield

64710

GSK Investigational Site, Monterrey

67000

GSK Investigational Site, Strasbourg

67098

GSK Investigational Site, Strasbourg

69495

GSK Investigational Site, Pierre-Bénite

72205

GSK Investigational Site, Little Rock

75013

GSK Investigational Site, Paris

77000

GSK Investigational Site, Melun

80054

GSK Investigational Site, Amiens

80100

GSK Investigational Site, Napoli

85925

GSK Investigational Site, La Roche-sur-Yon

87042

GSK Investigational Site, Limoges

89502

GSK Investigational Site, Reno

90502

GSK Investigational Site, Torrance

95100

GSK Investigational Site, Argenteuil

95819

GSK Investigational Site, Sacramento

98405

GSK Investigational Site, Tacoma

110017

GSK Investigational Site, New Delhi

111539

GSK Investigational Site, Moscow

111971

GSK Investigational Site, Bogotá

191104

GSK Investigational Site, Saint Petersburg

394066

GSK Investigational Site, Voronezh

400034

GSK Investigational Site, Mumbai

411001

GSK Investigational Site, Pune

411013

GSK Investigational Site, Pune

431001

GSK Investigational Site, Aurangabad

431003

GSK Investigational Site, Aurangabad

440003

GSK Investigational Site, Nagpur

450083

GSK Investigational Site, Ufa

454034

GSK Investigational Site, Chelyabinsk

500018

GSK Investigational Site, Hyderabad

603011

GSK Investigational Site, Nizhny Novgorod

614990

GSK Investigational Site, Perm

620039

GSK Investigational Site, Yekaterinburg

644111

GSK Investigational Site, Omsk

656045

GSK Investigational Site, Barnaul

700094

GSK Investigational Site, Kolkata

700099

GSK Investigational Site, Kolkata

7630000

GSK Investigational Site, Santiago

8900085

GSK Investigational Site, Santiago

14215-1199

GSK Investigational Site, Buffalo

X5000

GSK Investigational Site, Córdoba

C1039AAO

GSK Investigational Site, Buenos Aires

X5002AOQ

GSK Investigational Site, Córdoba

30130-100

GSK Investigational Site, Belo Horizonte

90035-903

GSK Investigational Site, Porto Alegre

01246-090

GSK Investigational Site, São Paulo

01323903

GSK Investigational Site, São Paulo

04037-003

GSK Investigational Site, São Paulo

05403-010

GSK Investigational Site, São Paulo

V6Z 1Y6

GSK Investigational Site, Vancouver

K1H 8L6

GSK Investigational Site, Ottawa

K1Y 4E9

GSK Investigational Site, Ottawa

H4J 1C5

GSK Investigational Site, Montreal

J5R 6J5

GSK Investigational Site, Québec

J7Z 5T3

GSK Investigational Site, Saint-Jérôme

470-1192

GSK Investigational Site, Aichi

231-8682

GSK Investigational Site, Kanagawa

251-0041

GSK Investigational Site, Kanagawa

534-0021

GSK Investigational Site, Osaka

350-0495

GSK Investigational Site, Saitama

113-8519

GSK Investigational Site, Tokyo

150-8935

GSK Investigational Site, Tokyo

162-8543

GSK Investigational Site, Tokyo

162-8655

GSK Investigational Site, Tokyo

5223 GZ

GSK Investigational Site, 's-Hertogenbosch

4818 CK

GSK Investigational Site, Breda

7512 KZ

GSK Investigational Site, Enschede

6532 SZ

GSK Investigational Site, Nijmegen

3083 AN

GSK Investigational Site, Rotterdam

Callao 2

GSK Investigational Site, Lima

Lima 11

GSK Investigational Site, Lima

Lima 1

GSK Investigational Site, Lima

85-030

GSK Investigational Site, Bydgoszcz

30-688

GSK Investigational Site, Krakow

61-285

GSK Investigational Site, Poznan

02-507

GSK Investigational Site, Warsaw

51-149

GSK Investigational Site, Wroclaw

08003

GSK Investigational Site, Barcelona

08907

GSK Investigational Site, L'Hospitalet de Llobregat

M13 9WL

GSK Investigational Site, Manchester

NE2 4HH

GSK Investigational Site, Newcastle

L7 8XP

GSK Investigational Site, Liverpool