42
Participants
Start Date
January 6, 2021
Primary Completion Date
January 30, 2027
Study Completion Date
December 30, 2027
Magnetic Resonance Imaging
60-cm wide bore 3T scanner (Siemens AG, Erlangen, Germany) with a 32-channel pelvic phased-array coil placed over the bladder.
Gadobutrol intravesical administration (4mM)
A paramagnetic macrocyclic gadolinium-based contrast agent administered intravenously for use in magnetic resonance imaging. Contrast-enhancement is a result of the neutral complex of gadolinium and dihydroxy-hydroxymethylpropyl- tetraazacyclododecane-triacetic acid (butrol).
Ferumoxytol intravesical administration (5 mM)
An iron preparation (Fe3O4) approved for intravenous treatment of anemia in the setting of renal failure, comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate shell in an isotonic, neutral pH solution.
RECRUITING
UPMC Department of Urology, Pittsburgh
National Cancer Institute (NCI)
NIH
Jodi Maranchie
OTHER