A Study to Evaluate the Safety and Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Melrilimab (GSK3772847) in Healthy Participants

PHASE1CompletedINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

July 21, 2020

Primary Completion Date

December 21, 2020

Study Completion Date

December 21, 2020

Conditions
Healthy VolunteersAsthma
Interventions
BIOLOGICAL

melrilimab (GSK3772847) 70 milligram (mg)

melrilimab (GSK3772837) will be available at a dose strength of 70 milligram per milliliter (mg/mL) in a 3 milliliter (mL) glass vial.

BIOLOGICAL

melrilimab (GSK3772847) 140 milligram (mg)

Two doses of melrilimab (GSK3772837) 70 milligram per milliliter (mg/mL) will be administered to achieve a dose strength of 140 milligram per milliliter (mg/mL)

OTHER

Placebo

Placebo to match melrilimab (GSK3772847) will be available in the form of solution for injection in a 3 milliliter (mL) glass vial.

Trial Locations (1)

92801

GSK Investigational Site, Anaheim

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY