Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse

Participants will receive 160 mg with breakfast on day 1 of bed rest and 40 mg with breakfast on days 2-5.

Participants will receive 100 mg on days 1-5 of bed rest.

Participants will receive Placebo on days 1-5 of bed rest.

Participants will be tested for passive leg movement on baseline day 1, bed rest day 1, and post bed rest.

Participants will undergo plantar flexion on baseline day 2, pre bed rest, and post bed rest.

Participants will undergo isometric knee extension on baseline day 2, pre bed rest, and post bed rest.

Participants will undergo 5 days bed rest after 5 day baseline assessments