EXHIT ENTRE Comparative Effectiveness Trial

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

344

Participants

Timeline

Start Date

August 9, 2021

Primary Completion Date

April 30, 2025

Study Completion Date

October 31, 2025

Conditions
Substance Use DisorderOpioid Use Disorder, ModerateOpioid Use Disorder, Severe
Interventions
DRUG

Extended Release Buprenorphine

XR-BUP administration prior to hospital discharge will increase engagement in OUD care on the 34th day following hospital discharge more than is currently afforded by ACS TAU approaches (e.g., methadone, SL-BUP, and naltrexone).

DRUG

Treatment as Usual

Community standard medication for opioid use disorder (e.g., methadone, sublingual buprenorphine, naltrexone) initiated prior to hospital discharge.

Trial Locations (6)

15213

University of Pittsburgh Medical Center, Pittsburgh

21224

Johns Hopkins Bayview Medical Center, Baltimore

55404

Hennepin Healthcare Research Institute, Minneapolis

06520

Yale New Haven Hospital, New Haven

02114

Massachusetts General Hospital, Boston

02118

Boston University, Boston

All Listed Sponsors
collaborator

National Institute on Drug Abuse (NIDA)

NIH

collaborator

The Emmes Company, LLC

INDUSTRY

lead

Hennepin Healthcare Research Institute

OTHER