ProTarget - A Danish Nationwide Clinical Trial on Targeted Cancer Treatment Based on Genomic Profiling

PHASE2RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

August 24, 2020

Primary Completion Date

April 30, 2029

Study Completion Date

April 30, 2030

Conditions
CancerTumorsNeoplasmsNeoplasia
Interventions
DRUG

Alectinib

Alectinib treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Alectinib might be expected based on their molecular tumor profile.

DRUG

Atezolizumab

Atezolizumab treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Atezolizumab might be expected based on their molecular tumor profile.

DRUG

Avelumab

Avelumab treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Avelumab might be expected based on their molecular tumor profile.

DRUG

Axitinib

Axitinib treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Axitinib might be expected based on their molecular tumor profile.

DRUG

Erlotinib

Erlotinib treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Erlotinib might be expected based on their molecular tumor profile.

DRUG

Vemurafenib plus Cobimetinib (combination)

Vemurafenib plus Cobimetinib treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Vemurafenib plus Cobimetinib might be expected based on their molecular tumor profile.

DRUG

Trastuzumab plus Pertuzumab (combination)

Trastuzumab plus Pertuzumab treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Trastuzumab plus Pertuzumab might be expected based on their molecular tumor profile.

DRUG

Trastuzumab emtansine

Trastuzumab emtansine treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Trastuzumab emtansine might be expected based on their molecular tumor profile.

DRUG

Vismodegib

Vismodegib treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Vismodegib might be expected based on their molecular tumor profile.

DRUG

Niraparib

Niraparib treatment for patients with an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma, who are not eligible for on-label treatment but for whom anti-tumor activity of Niraparib might be expected based on their molecular tumor profile.

Trial Locations (7)

2100

RECRUITING

Rigshospitalet, Copenhagen

2730

NOT_YET_RECRUITING

Herlev Hospital, Herlev

4000

NOT_YET_RECRUITING

Zealand University Hospital, Roskilde

5000

NOT_YET_RECRUITING

Odense University Hospital, Odense

7100

NOT_YET_RECRUITING

Vejle Sygehus, Vejle

8200

NOT_YET_RECRUITING

Aarhus University Hospital, Aarhus

9000

NOT_YET_RECRUITING

Aalborg University Hospital, Aalborg

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Roche Pharma AG

INDUSTRY

collaborator

Pfizer

INDUSTRY

collaborator

GlaxoSmithKline

INDUSTRY

lead

Ulrik Lassen

OTHER