Dose Reduction of IL17 and IL23 Inhibitors in Psoriasis

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

244

Participants

Timeline

Start Date

August 20, 2020

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
PsoriasisPsoriasis Vulgaris
Interventions
DRUG

Secukinumab

Maintenance/normal dose is 300 mg/4 weeks. First dose reduction step: 300 mg/6 weeks. Second dose reduction step: 300 mg/8 weeks.

DRUG

Ixekizumab

Maintenance/normal dose is 80 mg/4 weeks. First dose reduction step: 80 mg/6 weeks. Second dose reduction step: 80 mg/8 weeks

DRUG

Brodalumab

Maintenance/normal dose is 210 mg/2 weeks. First dose reduction step: 210 mg/3 weeks. Second dose reduction step: 210 mg/4 weeks.

DRUG

Guselkumab

Maintenance/normal dose is 100 mg/8 weeks. First dose reduction step: 100 mg/12 weeks. Second dose reduction step: 100 mg/16 weeks.

DRUG

Risankizumab

Maintenance/normal dose is 150 mg every 12 weeks. First dose reduction step: 150mg/18 weeks. Second dose reduction step: 150mg/24 weeks.

DRUG

Tildrakizumab

Maintenance/normal dose is 100 mg or 200 mg every 12 weeks. First dose reduction step: 100 mg or 200 mg/18 weeks. Second dose reduction step: 100 mg or 200 mg/24 weeks.

DRUG

Bimekizumab

Maintenance/normal dose is 320 mg/8 weeks. First dose reduction step: 320 mg/12 weeks. Second dose reduction step: 320 mg/16 weeks.

Trial Locations (19)

9000

Ghent University Hospital, Ghent

Unknown

ULB Erasme, Brussels

AZ Maria Middelares, Ghent

AZ St Lucas, Ghent

UCL Saint Luc, Leuven

UZ Leuven, Leuven

CHU Liege, Liège

Dermatologie Maldegem, Maldegem

Ziekenhuisgroep Twente, Almelo

Bravis hospital, Bergen op Zoom

Amphia Hospital, Breda

Slingeland hospital, Doetinchem

Catharina hospital, Eindhoven

UMC Groningen, Groningen

Maastricht UMC, Maastricht

Erasmus MC, Rotterdam

UMC Utrecht, Utrecht

Máxima Medisch Centrum, Veldhoven

6500HB

Radboudumc, Nijmegen

All Listed Sponsors
collaborator

ZonMw: The Netherlands Organisation for Health Research and Development

OTHER

collaborator

Belgium Health Care Knowledge Centre

OTHER_GOV

collaborator

University Hospital, Ghent

OTHER

lead

Radboud University Medical Center

OTHER