Neoadjuvant Nivolumab and Chemotherapy in Patients With Localized Triple-negative Breast Cancer

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

November 19, 2020

Primary Completion Date

March 20, 2023

Study Completion Date

May 31, 2026

Conditions
Triple Negative Breast Cancer
Interventions
DRUG

Paclitaxel

-Given standard of care

DRUG

Carboplatin

-Given standard of care

BIOLOGICAL

Nivolumab

-Given standard of care

BIOLOGICAL

Cabiralizumab

-Will be provided by Bristol Myers Squibb

PROCEDURE

Tumor biopsy

-Baseline, week 5, surgery, and at time of relapse (optional)

PROCEDURE

Bone marrow

-Time of port placement (baseline), time of surgery, and time of recurrence (optional)

PROCEDURE

Blood draw

-Baseline, week 5, prior to surgery , post-surgery follow-up (typically 3-4 weeks post-surgery), and disease progression (optional)

Trial Locations (1)

63110

Washington University School of Medicine, St Louis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Washington University School of Medicine

OTHER

NCT04331067 - Neoadjuvant Nivolumab and Chemotherapy in Patients With Localized Triple-negative Breast Cancer | Biotech Hunter | Biotech Hunter