CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition

PHASE2RecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

June 22, 2020

Primary Completion Date

May 31, 2027

Study Completion Date

February 29, 2028

Conditions
Kidney CancerRenal Cell Carcinoma
Interventions
DRUG

Cabozantinib

2 x 20 mg capsules taken orally daily

DRUG

Nivolumab

480mg IV on first day of each 28-day cycle

PROCEDURE

Cytoreductive nephrectomy

Surgery removing as much tumor tissue as possible, possibly including surrounding tissues.

Trial Locations (4)

10032

RECRUITING

Columbia University Irving Medical Center, New York

43221

RECRUITING

Ohio State University Wexner Medical Center, Columbus

44012

RECRUITING

Cleveland Clinic, Cleveland

08903

RECRUITING

The Rutgers Cancer Institute of New Jersey, New Brunswick

Sponsors
All Listed Sponsors
collaborator

Exelixis

INDUSTRY

collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Mark Stein

OTHER