Study of Naltrexone-Induced Blockade of Antidepressant Effects

PHASE4CompletedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

July 1, 2017

Primary Completion Date

July 15, 2018

Study Completion Date

July 15, 2018

Conditions
DepressionMajor Depressive Disorder
Interventions
DRUG

Naltrexone 50 Mg Oral Tablet

Naltrexone hydrochloride (ReVia®. Toronto, ON: Teva Canada Limited; 2015) (onset of action: ≥15 minutes; peak effect: \~1 hour; duration: \~24 hours).

DRUG

Placebo oral tablet

Placebo tablet that has no inherent power to produce an effect. In the inert pill condition, participants will receive an oral placebo tablet.

Trial Locations (1)

15213

Bellefield Towers, Pittsburgh

Sponsors
All Listed Sponsors
collaborator

Brain & Behavior Research Foundation

OTHER

lead

Marta Peciña, MD PhD

OTHER