Efficiency of an Algorithm Derived From Corneal Tomography Parameters to Distinguish Highly Susceptible Corneas to Ectasia From Healthy

CompletedOBSERVATIONAL
Enrollment

588

Participants

Timeline

Start Date

January 1, 2012

Primary Completion Date

January 1, 2018

Study Completion Date

January 1, 2018

Conditions
Keratoconus, Artificial Intelligence, Support Vector Machine
Interventions
DIAGNOSTIC_TEST

Corneal tomography multivariate index derived from a support vector machine (CTMVI).

MATHEMATICAL ALGORITHM: To build the equation extracted from SVM, 58 variables were used, some of them were extracted from the spreadsheet.. After the construction of these 58 feature vectors (FV), an SVM-derived index was created, which was called the corneal tomography multivariate index derived from a support vector machine (CTMVI). Considering that each patient represents a point on a cartesian plane with 58 dimensions (each coordinate representing one of the 58 FV), the role of SVM is to find the hyperplane that best separates the CG, KCG, and VAE-NT G subjects. A hyperplane is algebraically described by a linear equation; in this case, there are 59 coefficients, 58 of which are related to the FV and one independent coefficient representing the bias (which is a possible parallel dislocation of a given hyperplane).

All Listed Sponsors
collaborator

Fundação de Amparo à Pesquisa do Estado de São Paulo

OTHER_GOV

lead

Gildasio Castello de Almeida Junior

OTHER

NCT04313387 - Efficiency of an Algorithm Derived From Corneal Tomography Parameters to Distinguish Highly Susceptible Corneas to Ectasia From Healthy | Biotech Hunter | Biotech Hunter