Continuation of Protease-Inhibitor Based Second-Line Therapy vs. Switch to B/F/TAF in Virologically Suppressed Adults

PHASE4UnknownINTERVENTIONAL
Enrollment

386

Participants

Timeline

Start Date

September 1, 2020

Primary Completion Date

May 31, 2022

Study Completion Date

November 30, 2022

Conditions
HIV-1-infectionAntiretroviral Therapy
Interventions
DRUG

Continuation of boosted PI

"Continuation of the same second-line regimen taken prior to entry:~LPVr 400 mg/100 mg BID or ATVr 300 mg/100 mg QD + 2 NRTIs"

DRUG

B/F/TAF

Single-tablet, fixed dose combination of bictegravir 50 mg/emtricitabine 200 mg/tenofovir alafenamide 25 mg (B/F/TAF) administered orally, once daily.

Trial Locations (1)

Unknown

GHESKIO, Port-au-Prince

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Brigham and Women's Hospital

OTHER

collaborator

Harvard Medical School (HMS and HSDM)

OTHER

collaborator

Analysis Group, Inc.

INDUSTRY

collaborator

Weill Medical College of Cornell University

OTHER

lead

Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic

OTHER