A Study of Anlotinib Combined With AK105 Injection in Subjects With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Advanced Solid Tumor

PHASE2UnknownINTERVENTIONAL
Enrollment

138

Participants

Timeline

Start Date

March 31, 2020

Primary Completion Date

December 31, 2022

Study Completion Date

December 31, 2022

Conditions
MSI-H or dMMR Advanced Solid Tumors
Interventions
DRUG

AK105

AK105 is a humanized monoclonal antibody that specifically binds to PD-1. AK105 has a typical antibody structure and is composed of two lgG1 subtype heavy chains and two kappa subtypes light chains covalently linked by disulfide bonds.

DRUG

Anlotinib

A multi-target receptor tyrosine kinase inhibitor.

Trial Locations (9)

100010

Beijing Hospital, Beijing

100021

Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

100032

Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing

102206

Peking University International Hospital, Beijing

150030

The Third Affiliated Hospital of Harbin Medical University, Harbin

210000

Jiangsu Cancer Hospital, Nanjing

300060

Tianjin Cancer Hospital, Tianjin

710000

The Second Affiliated Hospital of The PLA Air Force Medical University, Xi’an

710061

Shanxi Cancer Hospital, Xi’an

All Listed Sponsors
lead

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY