Study of CAbozantinib in Combination with AtezolizumaB for Muscle-Invasive BladdEr Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

May 21, 2020

Primary Completion Date

June 30, 2025

Study Completion Date

December 31, 2025

Conditions
Bladder Cancer
Interventions
DRUG

Cabozantinib

Cabozantinib 40 mg orally daily for 3 cycles

DRUG

Atezolizumab

Atezolizumab 1200 mg IV every 3 weeks for 3 cycles

PROCEDURE

Cystectomy

Patients will receive three cycles of treatment prior to cystectomy unless they discontinue treatment for unacceptable toxicity or progressive disease by RECIST v1.1 or withdraw consent.

Trial Locations (6)

14642

University of Rochester Medical Center, Rochester

23298

Virginia Commonwealth University, Richmond

37232

Vanderbilt-Ingram Cancer Center, Nashville

53226

Froedtert and The Medical College of Wisconsin, Milwaukee

63110

Washington University School of Medicine, St Louis

07601

John Theurer Cancer Center, Hackensack

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Exelixis

INDUSTRY

collaborator

Genentech, Inc.

INDUSTRY

collaborator

Medical College of Wisconsin

OTHER

lead

Deepak Kilari

OTHER

NCT04289779 - Study of CAbozantinib in Combination with AtezolizumaB for Muscle-Invasive BladdEr Cancer | Biotech Hunter | Biotech Hunter