18
Participants
Start Date
September 16, 2020
Primary Completion Date
June 1, 2026
Study Completion Date
June 1, 2037
CD30.CAR-EBVST cells
The dose is based on the number of CD30.CAR-expressing cells. In our previous study the highest dose was 2 × 10\^8 cells/m2 and we did not reach an MTD. This will be administered as a single infusion of the full dose for each level, which was already shown to be safe in the first 3 patients treated at dose level 3. Since we have not observed any dose limiting toxicities at the current dose level (Dose Level 3 as of June 2022), we propose to include a new higher dose level (8 × 10\^8).There will be a gap of 4 weeks between the first and second patient, and between the second and the third patient, on each dose level.
RECRUITING
Houston Methodist Hospital, Houston
RECRUITING
Texas Children's Hospital, Houston
The Methodist Hospital Research Institute
OTHER
Baylor College of Medicine
OTHER