Assess the Safety of Immunotherapy Induction With Tremelimumab and Durvalumab Prior to Chemoradiotherapy and/or Resection in the Treatment

The IP will be given to the patient as long as there is a clinical benefit, in invertigator's judgment. Per day, 1500 mg

Per day 75mg

500 mg/m2 on day 1 every 3 weeks for 2 cycles

6 mg / m2 on day 1 every 3 weeks for 2 cycles

Once-daily fraction, 2 Gy per fraction. Total dose is 60 Gy.

After CIT-CRT