Intravitreal Brolucizumab in Neovascular Age-related Macular Degeneration With Limited Response to Aflibercept

PHASE4TerminatedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

July 20, 2020

Primary Completion Date

November 22, 2021

Study Completion Date

November 22, 2021

Conditions
Neovascular Age-related Macular Degeneration
Interventions
DRUG

Brolucizumab 6 mg solution for intravitreal injection

All consenting, enrolled patients (irrespectively of maximum recurrence-free interval under aflibercept pretreatment) will receive an intravitreal injection of brolucizumab 6 mg at baseline (week 0), at week 4 and each of the following treat and extend visits. At each visit all patients will undergo an OCT assessment. For all patients extension of treatment intervals is only possible 2-week-stepwise, e.g. 4, 6, 8 weeks etc.

Trial Locations (1)

4102

Vista Klinik, Binningen

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

Vista Klinik

OTHER

NCT04287348 - Intravitreal Brolucizumab in Neovascular Age-related Macular Degeneration With Limited Response to Aflibercept | Biotech Hunter | Biotech Hunter