Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX)

PHASE2CompletedINTERVENTIONAL
Enrollment

141

Participants

Timeline

Start Date

June 3, 2020

Primary Completion Date

September 1, 2023

Study Completion Date

March 21, 2024

Conditions
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Interventions
DRUG

Nivolumab + Paclitaxel

"Combination treatment: Nivolumab 240 mg will be administered via IV infusion every 2 weeks. Paclitaxel 80mg/m2 will be administered via IV infusion weekly. After 12 weeks from the start of the combined treatment paclitaxel will be stopped.~Maintenance treatment with nivolumab 480 mg every 4 weeks will start two weeks after the last administration of nivolumab 240 mg. Once nivolumab is administered at 480 mg, paclitaxel can no longer be administered.~Nivolumab will be continued alone until disease progression, unacceptable toxicity or withdrawal of consent up to a maximum of 24 months."

DRUG

Cetuximab + Paclitaxel

"Combination treatment: Cetuximab 250 mg/m2 (first dose of 400 mg/m2) administered via IV infusion weekly plus weekly paclitaxel (80 mg/m2) administered via IV infusion.~After 12 weeks from the start of the combined treatment paclitaxel will be stopped and weekly cetuximab will be continued alone until disease progression, unacceptable toxicity or withdrawal of consent up to a maximum of 24 months."

Trial Locations (21)

15009

Centro Oncoloxico de Galicia, A Coruña

17007

Hospital Universitari de Girona Dr. Josep, Girona

18014

Hospital Universitario Virgen de las Nieves, Granada

20014

Hospital Universitario Donostia- Donostia Unibertsitate Ospitalea, San Sebastián

27003

Hospital Universitario Lucus Augusti, Lugo

28040

Hospital Clínico San Carlos, Madrid

29010

Hospital Universitario Regional de Málaga, Málaga

31008

Complejo Hospitalario de Navarra, Pamplona

37007

Complejo Asistencial Universitario de Salamanca, Salamanca

39008

Hospital Universitario Marqués de Valdecilla, Santander

41013

Hospital Universitario Virgen del Rocío, Seville

45004

Hospital Virgen de la Salud, Toledo

46010

Hospital Clínico Universitario de Valencia, Valencia

46026

Hospital Universitario y Politécnico la Fe, Valencia

50009

Hospital Clínico Universitario Lozano, Zaragoza

Hospital Universitario Miguel Servet, Zaragoza

08916

Hospital Universitari Germans Trias i Pujol de Badalona, Badalona

08035

Hospital Universitari Vall d'Hebron, Barcelona

08036

Hospital Clínic de Barcelona, Barcelona

08908

Institut Català D´Oncologia- Hospital Duran i Reynals, Barcelona

Unknown

Hospital 12 de Octubre, Madrid

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Apices Soluciones S.L.

INDUSTRY

lead

Grupo Español de Tratamiento de Tumores de Cabeza y Cuello

OTHER

NCT04282109 - Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX) | Biotech Hunter | Biotech Hunter