A Study of Evaluating Dual Inhibitor of PAK4 and NAMPT ATG-019 in Advanced Solid Tumors or Non-Hodgkin's Lymphoma

PHASE1TerminatedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

April 13, 2020

Primary Completion Date

October 2, 2023

Study Completion Date

October 2, 2023

Conditions
Solid Tumor, Non-Hodgkin's Lymphoma
Interventions
DRUG

ATG-019

ATG-019 30 mg QoD×3 is selected as the staring dose. Oral ATG-019 will be taken three times a week every other day (Days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22, 24, and 26) during each 28-day cycle.

COMBINATION_PRODUCT

ATG-019 + Niacin ER

ATG-019 60 mg is selected as starting dose. Oral ATG-019 will be taken three times a week every other day (Days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22, 24, and 26) during each 28-day cycle. And a starting dose of 500 mg niacin ER (may be titrated up to 1,000 mg of daily dose, per label) co-administered with each dose of ATG-019.

Trial Locations (8)

114

Tri-Service General Hospital (TSGH), Taipei

807

Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH), Kaohsiung City

40447

China Medical University Hospital (CMUH), Taichang

70457

National Cheng Kung University Hospital (NCKUH), Tainan City

83301

Kaohsiung Chang Gung Memorial Hospital (CGMHKS), Kaohsiung City

200032

Fudan University Zhongshan Hospital, Shanghai

200092

Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine, Shanghai

210029

Jiangsu Province Hospital, Nanjing

Sponsors
All Listed Sponsors
lead

Antengene Therapeutics Limited

INDUSTRY

NCT04281420 - A Study of Evaluating Dual Inhibitor of PAK4 and NAMPT ATG-019 in Advanced Solid Tumors or Non-Hodgkin's Lymphoma | Biotech Hunter | Biotech Hunter