Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome

NARecruitingINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

February 2, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Postural Tachycardia SyndromeOrthostatic Intolerance
Interventions
OTHER

RespirAct™ system (Thornhill Research Inc., Toronto, Canada)

"1. HUTT with Normal Breathing in Room Air (No gas interventions will be applied)~2. HUTT with Normal Breathing and ETCO2 clamped at baseline levels~3. HUTT with Normal Breathing and Mild Hypercapnia (the ETCO2 will be clamped at 45mmHg )~4. HUTT with Normal Breathing and High Hypercapnia (the ETCO2 will be clamped at 55mmHg)~5. HUTT with Fast, Deep Breathing and resultant Hypocapnia Participant will be coached to breath around 15 breath per min.No gas interventions will be applied~6. HUTT with Fast, Deep Breathing and ETCO2 clamped at baseline levels. Participant will be coached to breath around 15 breath per min, with ETCO2 clamped to baseline levels."

Trial Locations (1)

T2N 4Z6

RECRUITING

University of Calgary, Calgary

All Listed Sponsors
lead

University of Calgary

OTHER