Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

337

Participants

Timeline

Start Date

June 16, 2020

Primary Completion Date

October 14, 2030

Study Completion Date

October 21, 2033

Conditions
Plasma Cell Myeloma
Interventions
DRUG

Isatuximab SAR650984

Pharmaceutical for: Solution for infusion Route of administration: Intravenous

DRUG

Lenalidomide

Pharmaceutical form: Capsules Route of administration: Oral

DRUG

Dexamethasone

Pharmaceutical form: Tablets and solution for injection Route of administration: Oral and intravenous

DRUG

Montelukast or equivalent

Auxiliary Medicinal Product (AxMP)/pre-medication; ATC code: R03DC03; Pharmaceutical form: tablet; Route of administration: Oral;

DRUG

Acetaminophen

AxMP/pre-medication ATC code: N02BE01 Pharmaceutical form: tablet/ampule/capsule; Route of administration: Intravenous (IV) or per os (PO)

DRUG

Diphenhydramine or equivalent

AxMP/pre-medication ATC code: R06AA02 Pharmaceutical form: ampule; Route of administration: Intravenous

DRUG

Methylprednisolone or equivalent

AxMP/pre-medication; ATC code: H02AB04; Pharmaceutical form: vial; Route of administration: Intravenous

Trial Locations (105)

1083

Investigational Site Number :3480003, Budapest

1097

Investigational Site Number :3480001, Budapest

2100

Investigational Site Number :2080005, Copenhagen

2170

Investigational Site Number :0360008, Liverpool

2298

Investigational Site Number :0360005, Waratah

2500

Investigational Site Number :0360001, Wollongong

3065

Investigational Site Number :0360002, Fitzroy

3081

Investigational Site Number :0360007, Heidelberg West

3121

Investigational Site Number :0360004, Richmond

3204

Investigational Site Number :5540001, Hamilton

4000

Investigational Site Number :2080002, Roskilde

4032

Investigational Site Number :3480002, Debrecen

5021

Investigational Site Number :5780002, Bergen

6009

Investigational Site Number :0360006, Nedlands

7400

Investigational Site Number :3480004, Kaposvár

8200

Investigational Site Number :2080003, Aarhus N

9000

Investigational Site Number :2080001, Aalborg

10676

Investigational Site Number :3000002, Athens

11528

Investigational Site Number :3000001, Athens

12808

Investigational Site Number : 2030001, Prague

20089

Investigational Site Number :3800001, Rozzano

20246

Investigational Site Number :2760001, Hamburg

27103

Novant Health Forsyth Medical Center Site Number : 8401015, Winston-Salem

28041

Investigational Site Number :7240005, Madrid

28204

Presbyterian Hospital Site Number : 8400015, Charlotte

31008

Investigational Site Number :7240006, Pamplona

32256

Cancer Specialist of North Florida Site Number : 8400011, Jacksonville

33136

University of Miami Site Number : 8400012, Miami

34214

Investigational Site Number : 7920004, Istanbul

34390

Investigational Site Number : 7920002, Istanbul

35033

Investigational Site Number :2500001, Rennes

35040

Investigational Site Number : 7920003, Izmir

37007

Investigational Site Number :7240007, Salamanca

37203

Tennessee Oncology Site Number : 8400006, Nashville

38043

Investigational Site Number :2500007, Grenoble

40138

Investigational Site Number :3800003, Bologna

46017

Investigational Site Number :7240002, Valencia

47014

Investigational Site Number :3800006, Meldola

49100

Investigational Site Number :3760005, Petah Tikva

50005

Investigational Site Number : 2030005, Hradec Králové

50009

Investigational Site Number :7240003, Zaragoza

57085

Investigational Site Number :2500009, Ars-Laquenexy

59037

Investigational Site Number :2500003, Lille

60032

Investigational Site Number :3800005, Ancona

62500

Investigational Site Number : 2030004, Brno

64109

Investigational Site Number :2500010, Bayonne

64239

Investigational Site Number :3760003, Tel Aviv

69120

Investigational Site Number :2760002, Heidelberg

70852

Investigational Site Number : 2030003, Ostrava - Poruba

75012

Investigational Site Number :2500005, Paris

75013

Investigational Site Number :2500011, Paris

77030

~University of Texas - MD Anderson Cancer Center Site Number : 8400002, Houston

77900

Investigational Site Number : 2030002, Olomouc

80218

Colorado Blood Cancer Institute Site Number : 8400007, Denver

85925

Investigational Site Number :2500006, La Roche-sur-Yon

86021

Investigational Site Number :2500002, Poitiers

90024

UCLA Site Number : 8400010, Los Angeles

91031

Investigational Site Number :3760001, Jerusalem

91120

Investigational Site Number :3760002, Jerusalem

110022

Investigational Site Number :1560005, Shenyang

200032

Investigational Site Number :1560004, Shanghai

300020

Investigational Site Number :1560001, Tianjin

310003

Investigational Site Number :1560002, Hangzhou

Investigational Site Number :1560003, Hangzhou

330006

Investigational Site Number :1560006, Nanchang

5265601

Investigational Site Number :3760006, Ramat Gan

7747629

Investigational Site Number :3760004, Ashdod

02115

Dana Farber Cancer Institute Site Number : 8400001, Boston

04537-081

Investigational Site Number :0760002, São Paulo

T6G 1Z2

Investigational Site Number :1240004, Edmonton

E1C 6Z8

Investigational Site Number :1240005, Moncton

H1T 2M4

Investigational Site Number :1240001, Montreal

PC 54007

Investigational Site Number :3000003, Thessaloniki

Unknown

Investigational Site Number :3720001, Dublin

Investigational Site Number :3720002, Dublin

Investigational Site Number :3720003, Dublin

Investigational Site Number :5540004, Christchurch

05100

Investigational Site Number :3800002, Terni

467-8602

Investigational Site Number :3920002, Nagoya

296-8602

Investigational Site Number :3920006, Kamogawa-shi

371-8511

Investigational Site Number :3920008, Maebashi

311-3193

Investigational Site Number :3920005, Higashiibaraki-gun

701-1192

Investigational Site Number :3920003, Okayama

411-8777

Investigational Site Number :3920009, Sunto-gun

150-8935

Investigational Site Number :3920001, Shibuya-ku

08661

Investigational Site Number :4400001, Vilnius

0450

Investigational Site Number :5780001, Oslo

85-168

Investigational Site Number :6160006, Bydgoszcz

93-510

Investigational Site Number :6160002, Lodz

80-214

Investigational Site Number :6160008, Gdansk

41-500

Investigational Site Number :6160005, Chorzów

06351

Investigational Site Number :4100004, Gangnam-gu

03080

Investigational Site Number :4100003, Seoul

03722

Investigational Site Number :4100001, Seoul

06591

Investigational Site Number :4100002, Seoul

08036

Investigational Site Number :7240004, Barcelona

08041

Investigational Site Number :7240001, Barcelona

413 45

Investigational Site Number :7520001, Gothenburg

251 87

Investigational Site Number :7520003, Helsingborg

06010

Investigational Site Number : 7920005, Ankara

06620

Investigational Site Number : 7920001, Ankara

BH7 7DW

Investigational Site Number :8260002, Bournemouth

SE1 7EH

Investigational Site Number :8260003, London

LE15WW

Investigational Site Number :8260001, Leicester

SO16 6YD

Investigational Site Number :8260004, Southampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Sanofi

INDUSTRY

NCT04270409 - Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma | Biotech Hunter | Biotech Hunter