NFL LONG Prospective Study

PHASE1Enrolling by invitationINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

March 12, 2020

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Concussion, Brain
Interventions
DRUG

[11C] PiB

Per study protocol static PET images will be acquired after IV infusion of CPiB to generate standard uptake values (SUVs). PET imaging is necessary in order to address the primary and secondary outcome measures as a component of neurological health (i.e., presence of proteinopathies empirically associated with neurodegenerative disease, cognitive decline, and neurological signs/symptoms). All groups will participate in this portion of the protocol.

DRUG

[18F] PBR111

Per study protocol static PET images will be acquired after IV infusion of F-PBR111 to generate standard uptake values (SUVs). PET imaging is necessary in order to address the primary and secondary outcome measures as a component of neurological health (i.e., presence of proteinopathies empirically associated with neurodegenerative disease, cognitive decline, and neurological signs/symptoms). All groups will participate in this portion of the protocol.

DRUG

[18F] Flortaucipir

Per study protocol static PET images will be acquired after IV infusion of F-T807 to generate standard uptake values (SUVs). PET imaging is necessary in order to address the primary and secondary outcome measures as a component of neurological health (i.e., presence of proteinopathies empirically associated with neurodegenerative disease, cognitive decline, and neurological signs/symptoms). All groups will participate in this portion of the protocol.

Trial Locations (3)

27599

University of North Carolina at Chapel Hill, Chapel Hill

53226

Medical College of Wisconsin, Milwaukee

02453

Boston Children's Hospital, Waltham

All Listed Sponsors
collaborator

Boston Children's Hospital

OTHER

collaborator

Medical College of Wisconsin

OTHER

collaborator

National Football League

OTHER

lead

University of North Carolina, Chapel Hill

OTHER