250
Participants
Start Date
March 12, 2020
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2025
[11C] PiB
Per study protocol static PET images will be acquired after IV infusion of CPiB to generate standard uptake values (SUVs). PET imaging is necessary in order to address the primary and secondary outcome measures as a component of neurological health (i.e., presence of proteinopathies empirically associated with neurodegenerative disease, cognitive decline, and neurological signs/symptoms). All groups will participate in this portion of the protocol.
[18F] PBR111
Per study protocol static PET images will be acquired after IV infusion of F-PBR111 to generate standard uptake values (SUVs). PET imaging is necessary in order to address the primary and secondary outcome measures as a component of neurological health (i.e., presence of proteinopathies empirically associated with neurodegenerative disease, cognitive decline, and neurological signs/symptoms). All groups will participate in this portion of the protocol.
[18F] Flortaucipir
Per study protocol static PET images will be acquired after IV infusion of F-T807 to generate standard uptake values (SUVs). PET imaging is necessary in order to address the primary and secondary outcome measures as a component of neurological health (i.e., presence of proteinopathies empirically associated with neurodegenerative disease, cognitive decline, and neurological signs/symptoms). All groups will participate in this portion of the protocol.
University of North Carolina at Chapel Hill, Chapel Hill
Medical College of Wisconsin, Milwaukee
Boston Children's Hospital, Waltham
Boston Children's Hospital
OTHER
Medical College of Wisconsin
OTHER
National Football League
OTHER
University of North Carolina, Chapel Hill
OTHER