Evaluation of UCPVax Plus Nivolumab as Second Line Therapy in Advanced Non Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

September 9, 2020

Primary Completion Date

November 22, 2023

Study Completion Date

November 28, 2024

Conditions
Advanced Non-small Cell Lung Cancer
Interventions
DRUG

UCPVax + Nivolumab

"UCPVax will be administrated at day 1 of week 1 ; 2 ; 3 ; 5 ; 6 ; 7 and then week 13 and every 2 months until months 12.~Nivolumab will be administrated at the dose of 480 mg at day 1 and then every 4 weeks until disease progression or unacceptable toxicity according to label.~At the end of COMBO phase, nivolumab will be continued every 4 weeks for maximum 24 months from the first administration, until disease progression or unacceptable toxicity according to standard of care."

DRUG

standard chemotherapy

Second line chemotherapy at the choice of the investigator

Trial Locations (8)

250000

CHU of Besançon, Besançon

Unknown

CHU Bordeaux, Bordeaux

Centre Georges François Leclerc, Dijon

Institut de Cancérologie Privé CCGM, Montpellier

CH Mulhouse, Mulhouse

CHU de Nîmes, Nîmes

Institut Jean Godinot, Reims

Institut de Cancérologie de l'Ouest, Saint-Herblain

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Fondation ARC

OTHER

lead

Centre Hospitalier Universitaire de Besancon

OTHER

NCT04263051 - Evaluation of UCPVax Plus Nivolumab as Second Line Therapy in Advanced Non Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter