Targeted Therapy and Avelumab in Merkel Cell Carcinoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

October 8, 2020

Primary Completion Date

July 31, 2027

Study Completion Date

July 31, 2027

Conditions
Metastatic Merkel Cell Carcinoma
Interventions
DRUG

Avelumab

All patients will receive avelumab intravenously (IV) at 10 mg/kg every 2 weeks for 24 months or until unacceptable toxicity or evidence of disease progression

RADIATION

External Beam Radiation Therapy (EBRT)

Patients allocated to Arm A will receive EBRT on 2 occasions, 8-10 weeks apart

RADIATION

Lutetium-177 (177Lu)-DOTATATE

"Patients allocated to Arm B will receive 177-Lu-DOTATATE treatment on 2 occasions, 8-10 weeks apart.~This treatment arm is now closed to recruitment."

Trial Locations (10)

2065

RECRUITING

Royal North Shore Hospital, Sydney

2250

RECRUITING

Gosford Hospital, Gosford

2259

RECRUITING

Wyong Hospital, Hamlyn Terrace

2290

RECRUITING

Lake Macquarie Private Hospital, Gateshead

2450

RECRUITING

Mid North Coast Cancer Institute - Coffs Harbour Health Campus, Coffs Harbour

3000

RECRUITING

Peter MacCallum Cancer Centre, Melbourne

4029

RECRUITING

Royal Brisbane and Women's Hospital, Brisbane

4102

RECRUITING

Princess Alexandra Hospital, Brisbane

5000

RECRUITING

Royal Adelaide Hospital, Adelaide

6009

RECRUITING

Sir Charles Gaidner Hospital, Perth

All Listed Sponsors
lead

Melanoma and Skin Cancer Trials Limited

OTHER