Driving Pressure and Postoperative Pulmonary Complications in Thoracic Surgery

NACompletedINTERVENTIONAL
Enrollment

1,300

Participants

Timeline

Start Date

March 2, 2020

Primary Completion Date

April 15, 2021

Study Completion Date

May 31, 2021

Conditions
One-Lung VentilationPostoperative ComplicationsDriving PressurePostoperative Pulmonary ComplicationThoracic SurgeryPositive End Expiratory Pressure
Interventions
OTHER

ventilation

"Driving Pressure Limited Ventilation~Positive end expiratory pressure is adjusted to minimize driving pressure, plateau pressure minus end expiratory pressure from 10 to 2 cmH2O during one-lung ventilation.~1\. Lung recruitment: stepwise increase of positive end expiratory pressure 5,10,15 cmH2O with tidal volume 5mL/kg, inspiratory:expiratory 1:1, respiratory rate 10. and driving pressure up to 20 cmH2O. Then decremental PEEP titration is performed using a volume-controlled ventilation until the lowest driving pressure (plateau pressure minus PEEP) is found. This individualized PEEP is adjusted during one-lung ventilation."

Trial Locations (1)

06351

Samsung medical center, Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Severance Hospital

OTHER

collaborator

Seoul National University Hospital

OTHER

collaborator

Asan Medical Center

OTHER

collaborator

Korea University Guro Hospital

OTHER

collaborator

The Catholic University of Korea

OTHER

lead

Samsung Medical Center

OTHER

NCT04260451 - Driving Pressure and Postoperative Pulmonary Complications in Thoracic Surgery | Biotech Hunter | Biotech Hunter