Dose Escalation Study of PF-07209326 in Healthy Participants and Participants With Sickle Cell Disease

PHASE1CompletedINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

February 5, 2020

Primary Completion Date

July 7, 2023

Study Completion Date

July 7, 2023

Conditions
HealthySickle Cell Anemia
Interventions
BIOLOGICAL

Placebo

Participants will receive matching placebo

BIOLOGICAL

PF-07209326

Participants will receive SC or IV single ascending doses

BIOLOGICAL

PF-07209326

SCD participants will receive a multiple dose of subcutaneous PF-07209326

Trial Locations (16)

10032

Columbia University Medical Center - Herbert Irving Pavilion, New York

CUIMC Research Pharmacy, New York

CUMC Research Pharmacy, New York

20060

Howard University College of Medicine, Washington D.C.

30322

Children's Healthcare of Atlanta - Egleston Hospital-Aflac Cancer and Blood Disorders Center, Atlanta

33023

Foundation for Sickle Cell Disease Research, Hollywood

33024

Foundation for Sickle Cell Disease Research, Hollywood

33908

Golisano Children's Hospital of Southwest Florida, Fort Myers

Lee Health - Golisano Children's Hospital of Southwest Florida, Fort Myers

55114

Prism Research LLC dba Nucleus Network, Saint Paul

60612

University of Illinois at Chicago Clinical Research Center, Chicago

University of Illinois at Chicago, Chicago

77004

UT Physicians Comprehensive Sickle Cell Center Houston, Houston

77030

Memorial Hermann clinical research unit, Houston

UT Physicians Comprehensive Sickle Cell Center Houston, Houston

06511

New Haven Clinical Research Unit, New Haven

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY