An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

195

Participants

Timeline

Start Date

March 9, 2020

Primary Completion Date

December 15, 2025

Study Completion Date

December 15, 2025

Conditions
Solid Tumors
Interventions
DRUG

XmAb24306

Participants will receive intravenous (IV) XmAb24306.

DRUG

Atezolizumab

Participants will receive IV XmAb24306 followed by IV atezolizumab

DRUG

XmAb24306

Participants will receive IV XmAb24306 followed by IV atezolizumab.

Trial Locations (29)

2610

GasthuisZusters Antwerpen, Wilrijk

3000

Parkville Cancer Clinical Trial Unit (PCCTU), Melbourne

13620

Seoul National University Bundang Hospital, Seongnam-si

14001

C.H. Regional Reina Sofia - PPDS, Córdoba

20089

Istituto Clinico Humanitas, Rozzano

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20141

Istituto Europeo Di Oncologia, Milan

28027

Clinica Universidad de Navarra-Madrid, Madrid

28040

START Madrid-FJD, Hospital Fundacion Jimenez Diaz, Madrid

31008

Clinica Universitaria de Navarra, Pamplona

37203

SCRI Oncology Partners, Nashville

46010

Hospital Clinico Universitario de Valencia, Valencia

48109

City of Hope Comprehensive Cancer Center, Ann Arbor

73104

The University of Oklahoma Health Sciences Center, Oklahoma City

85258

Honor Health Research Institute, Scottsdale

94304

Stanford Health Centre - Palo Alto, Palo Alto

94158-2545

University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco

06520

Yale University, New Haven

90560-030

Hospital de Clinicas de Porto Alegre HCPA PPDS, Porto Alegre

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo

M5G 2M9

Princess Margaret Hospital, Toronto

H3T 1E2

Sir Mortimer B Davis Jewish General Hospital, Montreal

1066 CX

Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam

1081 HV

VU Medisch Centrum, Amsterdam

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System - PPDS, Seoul

05505

Asan Medical Center - PPDS, Seoul

06351

Samsung Medical Center - PPDS, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY